منابع مشابه
Mitotic Diversity in Homeostatic Human Interfollicular Epidermis
Despite decades of skin research, regulation of proliferation and homeostasis in human epidermis is still insufficiently understood. To address the role of mitoses in tissue regulation, we utilized human long-term skin equivalents and systematically assessed mitoses during early epidermal development and long-term epidermal regeneration. We now demonstrate four different orientations: (1) horiz...
متن کاملMitotic activity in the human epidermis.
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متن کاملMitotic Langerhans Cells in the Normal Human Epidermis: Light and Electron Microscopic Observations in All Mitotic Phases
In three experiments of the normal human epidermis under different biopsy and fixative buffer conditions, Langerhans cells (LCs) in all mitotic phases were found with the Thin-Section-Reembedding and Ultrathin-Sectioning (TRUS) technique; two in the prophase, five in the metaphase, two in the anaphase and two in the telophase. The serial light microscopic examination showed many characteristic ...
متن کاملRobust control of mitotic spindle orientation in the developing epidermis
Progenitor cells must balance self-amplification and production of differentiated progeny during development and homeostasis. In the epidermis, progenitors divide symmetrically to increase surface area and asymmetrically to promote stratification. In this study, we show that individual epidermal cells can undergo both types of division, and therefore, the balance is provided by the sum of indiv...
متن کاملMucopolysaccharides in human epidermis.
In a previous publication on the Gram staining material of human epidermis we advanced the theory that keratohyalin contained a highly resistant mucopolysaccharide. In the course of normal keratinization this material was decomposed, while in parakeratotic and many other types of pathologic scales it was retained in the horny layer (1). The evidence presented was indirect: we found that the ext...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1939
ISSN: 0022-202X
DOI: 10.1038/jid.1939.25